What is dihydroquercetin?

Dihydroquercetin is a dihydroflavonol compound belonging to the vitamin P family. It is a widely used bioactive substance. Like other flavonoids, it has multiple biological activities in the human body, including antioxidant, free radical scavenging, antiviral, anti-inflammatory, vasodilating and antibacterial effects. Dihydroquercetin is a new food antioxidant in the food industry. Its antioxidant capacity is comparable to many natural and synthetic antioxidants. No toxic reactions have been observed at large doses, and no experiments have shown that it has teratogenic, allergenic and mutagenic effects on the fetus.

 

Effect of dihydroquercetin

 

Dihydroquercetin has strong antioxidant, anti-inflammatory and antitumor inhibitory activities, and has shown good pharmacological activity in the treatment of inflammation, tumors, microbial infections, oxidative stress, cardiovascular diseases and liver diseases.

 

1. Antitumor effect of dihydroquercetin

Dihydroquercetin exerts its antitumor effect through three pathways. On the one hand, it directly inhibits skin cancer, breast cancer, lung cancer, colorectal cancer and other cancers by increasing antioxidant capacity, improving the body's immune function and reducing cytokine levels. On the other hand, dihydroquercetin can increase the sensitivity of drug-resistant tumor cells to chemotherapy drugs, increase the cancer cell toxicity of cancer drugs and synergistically exert anticancer effects. At the same time, dihydroquercetin can provide protection and reduce the damage caused by chemotherapy drugs to normal cells and tissues.

 

2. Dihydroquercetin and liver health
Dihydroquercetin can prevent acute liver injury caused by pazopanib, acetaminophen, carbon tetrachloride, concanavalin A, etc., reduce the accumulation of hepatic lipids and prevent alcohol-related liver damage by improving the body's antioxidant capacity and reducing inflammatory factors. Dihydroquercetin has a protective effect on the liver and has a potential therapeutic effect on liver diseases such as acute liver injury and acute liver failure.

3. Dihydroquercetin and heart health
Dihydroquercetin improves cell stability and oxidative stress levels by improving antioxidant capacity, improving blood rheology indicators and myocardial pathological conditions, thereby having a certain protective effect on myocardial ischemia, protecting myocardial cells and playing a role in the treatment of coronary artery disease. Dihydroquercetin regulates oxidative stress, inhibits cell apoptosis, improves myocardial function, and thus reduces myocardial ischemia/reperfusion injury.

 

4. Dihydroquercetin and eye health
Dihydroquercetin is beneficial in the treatment of diabetic retinopathy through its antioxidant effect, improves the body's own antioxidant capacity and is anti-inflammatory. It can prevent optic nerve damage caused by formaldehyde exposure and protect retinal pigment epithelial cells. It can be used to prevent and treat age-related macular degeneration.

 

5. Dihydroquercetin and bone health
Dihydroquercetin can inhibit osteoclastogenesis, reduce ovariectomy-induced bone loss, enhance the therapeutic effect of sodium gluconate and sodium alendronate, better maintain femoral strength and bone density in osteoporotic rats [29], stimulate the synthesis of type I collagen fibers, promote the stability of collagen fiber structure, and promote joint health.

 

6. Dihydroquercetin and brain health
Dihydroquercetin has a protective effect on acute brain injury caused by cerebral ischemia through antioxidant and anti-inflammatory effects, and improves brain tissue energy metabolism and blood rheology indicators. Dihydroquercetin can inhibit the formation of β-amyloid protein, prevent β-amyloid protein aggregation, maintain brain cognitive function and cerebrovascular function, and thus has a therapeutic effect on cerebral amyloid angiopathy and Alzheimer's disease.

 

7. Dihydroquercetin and metabolic diseases
Dihydroquercetin exerts a hypotensive effect by reducing blood viscosity and vasodilation. Dihydroquercetin can improve diabetes and kidney diseases caused by diabetes by lowering blood sugar and insulin levels, lowering uric acid and creatinine. Dihydroquercetin has the effect of lowering uric acid by inhibiting the activity of hepatic xanthine oxidase and reducing the production of uric acid.

 

8. Other physiological activities of dihydroquercetin
Dihydroquercetin can significantly improve allergic reactions and relieve itching through anti-inflammatory effects, is beneficial to endotoxemia and reduces mortality. Dihydroquercetin can prevent colitis by inhibiting inflammatory factors, improving the intestinal barrier and regulating intestinal flora. Dihydroquercetin can prevent obesity by antioxidation and inhibiting lipid accumulation in fat cells. Dihydroquercetin can resist renal fibrosis by adjusting disturbed metabolism and delaying pathological changes in tissue.

 

dihydroquercetin market

 

Because dihydroquercetin has a special molecular structure of five phenolic hydroxyl groups, it is by far the most scarce natural potent antioxidant, which can effectively remove free radicals and toxins in the human body. Therefore, taxifolin has a broad spectrum of biological and pharmacological activities such as anti-inflammatory, antibacterial, anti-radiation, anti-cancer, anti-virus, regulation of immunity, clearance of melanin, and improvement of microcirculation. It is a precious raw material for the production of food, medicine and health products.

 

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