What's the Crocus Sativus Extract Benefits?

 

Crocus Sativus Extract is a product extracted from the upper part and stigma of the Crocus sativus L. style of the Iridaceae plant. The main components are picrocrocetin, carotene compounds, saffron, eucalyptol, pinene and other substances Contains a small amount of isorhamnetin, kaempferol, vitamin B1 and vitamin B2, etc. Saffron extract is a powerful scavenger of hydroxyl free radicals and superoxide free radicals. It can resist oxidation, improve mitochondrial function, inhibit optic nerve cell apoptosis, improve microcirculation, improve immunity, resist arteriosclerosis, resist oxidation, Lower blood fat, promote gallbladder and protect liver, prevent and treat osteoporosis, protect kidney and so on.

 

Sweet in taste, flat in nature, non-toxic. Go into the heart, Liver Channel. Promoting blood circulation and removing blood stasis, dissipating stagnation and resolving knots. Control anxiety and depression, chest and diaphragm fullness, vomiting blood, typhoid fever, trance, women's amenorrhea, postpartum blood stasis abdominal pain, tumbling and swelling.

 

 

 

1. The effect on the uterus
Saffron extract has excitatory effects on the isolated uterus and in vivo uterus of mice, guinea pigs, rabbits, dogs and cats. The pregnant uterus is more sensitive; the order of action intensity of various extracts of saffron is: decoction > ethanol extract > volatile components > ether extract. The effect of stimulating the uterus can be partially blocked by ergotoxine ethanesulfonate, and it is not sensitive to atropine. Therefore, it is believed that part of the effect on the uterus is a direct effect on uterine muscle cells, and part of it is related to adrenergic receptors.

 

2. Effects on the circulatory system
Saffron extract can lower the blood pressure of anesthetized dogs and cats and maintain it for a long time, and has an exciting effect on breathing. When the blood pressure is lowered, the volume of the kidney shrinks, which shows that the renal blood vessels contract, and it also has a contraction effect on the blood vessels of toads. It has a more significant inhibitory effect on the isolated toad heart. According to chemical analysis, the components that inhibit the heart are related to potassium salts, so the pharmacological research of saffron should first remove potassium salts in the future.

 

3. Anti-tumor effect
Saffron preparations have obvious anticancer and anticancer ability, especially saffron extract (dimethylcrocetin acid) has anticancer effects on leukemia, ovarian cancer, colon cancer, rhabdomyosarcoma, colon cancer, papillary sarcoma, squamous cell tumor and soft tissue sarcoma. Strong inhibitory effect. Its anti-cancer mechanism may be to destroy the DNA synthetase system, that is, to destroy the DNA-protein communication media such as topoisomerase II, which is crucial to the synthesis of cellular DNA, thereby inhibiting the synthesis of DNA and RNA to achieve the effect of inhibiting the growth of tumor cells . In addition, crocins also inhibit the activity of cellular protein kinases and the expression of proto-oncogenes.

 

4. The effect on the liver and gallbladder
The saffron extract has choleretic effect, and the active ingredients are α-crocetin sodium salt and saffron ester. α-crocetin can lower cholesterol and increase fat metabolism. It can be used in combination with traditional Chinese medicines such as hawthorn, cassia, and alisma to treat fatty liver.

 

5. Antioxidant effect
Saffron extract, especially saffron, can effectively inhibit the activity of oxygen free radicals and xanthine oxidase, showing antioxidant biological activity.

6. Protects the kidneys
By studying the rat C-BSA nephritis model, it was found that the phenomenon of proteinuria and renal pathological damage in the experimental group were alleviated. Among them, saffron is mainly through inhibiting cyclooxygenase and reducing the synthesis of prostaglandins, so as to achieve unobstructed renal capillaries, increase blood flow, and promote the repair of inflammatory damage. It is suggested that saffron can interfere with the occurrence of renal inflammation by improving the release of platelets and inflammatory mediator Chemicalbook.

 

7. Intervention for arrhythmia
The active ingredient crocetin in the saffron extract has a better effect on the ventricular arrhythmia model induced by aconitine, ouabain and calcium chloride, which provides an experimental basis for the use of saffron in the treatment of arrhythmia and provides a basis for further development. , the study of saffron as a traditional Chinese medicine preparation against arrhythmia and myocardial ischemia provides a feasible basis, suggesting that saffron may be called a new type of preventive and health-care traditional Chinese medicine for preventing cardiovascular and cerebrovascular diseases.

 

8. Regulate immune function
Saffron extract has obvious effects of promoting blood circulation, removing blood stasis, antibacterial and anti-inflammatory, etc., and then enhances the body's endurance and increases the content of immune cells, so as to improve the body's immunity, adjust the body's blood circulation, and balance the body's yin and yang.

 

9. Prevention and treatment of atherosclerosis
Saffron extract has a good curative effect on regulating blood fat, lowering blood pressure and then preventing and treating atherosclerosis.

 

10. Retinal protection
New Zealand white rabbits were used to make an animal model of high intraocular pressure, a certain dose of saffron extract was injected from the ear vein, once a day, and a high pressure control group was set up. The results showed that the number of retinal ganglion cells in the treatment group was significantly more than that in the hypertensive control group (P<0.05), indicating that the saffron extract could improve retinal blood circulation and block the effects of ischemia and hypoxia on retinal ganglion cells ( RGC) damage and protect RGC. It suggested that saffron extract may protect RGC by reducing free radicals in the retina and blocking the damage of free radicals to RGC membrane structure, subcellular organelles and nucleus.

 

11. Other functions
Saffron ethanol extract (CSE) prevents ethanol-induced suppression of long-term potentiation (LPT) in the hippocampus. In the zigzag gyrus of anesthetized mice, CSE (250mg·kg-1) can also effectively prevent the inhibition of LPT caused by acetaldehyde without affecting the learning function of mice. The water extract of saffron can significantly inhibit the reproductive toxicity of anticancer drugs such as cisplatin, cyclophosphamide, mitomycin C and urethan, and the inhibitory effect There was no significant relationship between the size and dose. This was mainly because saffron extract significantly reduced the effect of reproductive toxicity on hepatic glutathione S-transferase (GST).

 

 

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