What Are The Health Benefits Of Kaempferol?

Anti-cancer and anti-cancer
Kaempferol as the most common flavonoids, long-term diet can reduce the risk of cancer. Studies have reported that high intake of kaempferol can reduce the recurrence of advanced colorectal adenoma, and, compared with other flavonoids in the daily diet, high intake of kaempferol can also significantly reduce the risk of pancreatic cancer. The latest research shows that kaempferol can also inhibit hepatocyte growth factor (HGF) and its receptor tyrosine protein kinase, which are related to the growth and metastasis of children's medulloblastoma, so it can be prevented and treated by dietary kaempferol. Treat the disease.

 

Anti-infection and anti-inflammation
Studies have shown that kaempferol has good antibacterial activity and is also effective against methicillin-resistant Staphylococcus aureus (MRSA). The K-Br disc method shows that the concentration of 50mg/tablet can make the inhibition zone of MRSA reach 8.5 mm, it also has good antibacterial activity against Vibrio cholerae and Enterococcus faecalis. In terms of anti-virus, kaempferol can be inhibited in a concentration-dependent manner at non-cytotoxic concentrations.
In terms of anti-inflammation, kaempferol mainly achieves anti-inflammatory effect by inhibiting the expression of inflammatory factors.

 

Diabetes Prevention
Atherosclerosis (AS) is a chronic inflammatory disease of the blood vessel wall. Studies have shown that kaempferol can not only inhibit copper ion-induced oxidation of low-density lipoprotein (LDL) into oxidized low-density lipoprotein (ox-LDL) , and can also reduce the expression of CD 36 protein on the surface of THP-1 macrophages, prevent the cells from taking up ox-LDL, and thus prevent the occurrence of atherosclerosis.
Diabetes is an endocrine and metabolic disease that seriously threatens human health, and its incidence is increasing at an unprecedented rate. Studies have shown that kaempferol has the effect of acting as an agonist with the hypoglycemic drug rosiglitazone, but its adverse reactions are far weaker than rosiglitazone. It can increase the response of 3T3-L1 cells to glucose without affecting adipogenesis. The uptake of it indicates that it is expected to become a new generation of insulin sensitizer.

 

Neuroprotective effect of kaempferol
Kaempferol can protect nerve damage caused by oxidative stress by inhibiting oxidative stress response. Kaempferol can significantly protect SHSY5Y nerve cells and main neuron cells from the damage of rotenone, reduce protease cleavage and nucleus apoptosis, ROS level and mitochondrial hydroxyl compound content are also significantly reduced. This proves that kaempferol has a certain neuroprotective function and can be developed and utilized as a potential neuroprotective agent.

 

Protective Effects of Kaempferol on Liver and Myocardium
Yangan pills, which contain flavonoids such as kaempferol as the main ingredients, have been used in Asian countries for the treatment and prevention of liver diseases. Studies have found that kaempferol can protect the apoptosis of HL-7702 normal human liver cells induced by endoplasmic reticulum stress by inhibiting the expression of apoptosis protein CHOP. Using kaempferol to treat cardiomyocytes induced by regional hypoxia/reoxygenation (A/R), it can be found that kaempferol can significantly increase the expression of Bcl-2 through the mitochondrial pathway mediated by silent regulator 1 (SIRT1), showing Protective effect on A/R-induced cardiomyocyte apoptosis.

 

Atherosclerosis prevention and treatment function of kaempferol
Detecting the effect of kaempferol on New Zealand white rabbits of atherosclerosis model, it was found that after 10 weeks of mixed feeding of kaempferol and high cholesterol, compared with the group fed with high cholesterol alone, the intercellular adhesion molecule-1 (ICAM-1 ), vascular cell adhesion molecule-1 (VCAM-1), integrin, monocyte chemoattractant-1 (MCP-1) and other adhesion molecules gene levels and protein levels were significantly reduced, proving that kaempferol can effectively reduce Vascular inflammatory response, which has the potential function of preventing atherosclerosis. In addition, kaempferol is also the main anti-atherosclerotic active ingredient in Moringa oleifera, which has been listed as a potential therapeutic agent for hyperlipidemia, atherosclerosis and cardiovascular diseases.

 

Kaempferol's anti-diabetic function
Studies have found that kaempferol can significantly improve the glucose uptake ability of mature 3T3-L1 adipocytes stimulated by insulin, showing the potential function of preventing and treating diabetes. At the same time, kaempferol can also maintain normal blood lipid levels by lowering blood sugar and improving insulin sensitivity; through anti-oxidation, anti-inflammation, and inhibition of aldose reductase pathways, it can inhibit the occurrence of chronic complications in type 2 diabetic rats to a certain extent.

 

Osteoporosis prevention and treatment function of kaempferol
Kaempferol can activate the activity of estrogen receptors, promote the proliferation of osteoblasts, and improve the differentiation and mineralization of osteoblasts. Another study found that kaempferol can significantly increase the bone density of ovariectomized rats, slow down the loss of bone calcium and phosphorus in rat urine, and inhibit the activity of tartrate acid phospholipase and histone K in serum of ovariectomized rats. Micro-CT results show that kaempferol can significantly improve the trabecular bone structure of osteoporotic rats, which proves that kaempferol has a significant therapeutic effect on osteoporosis in ovariectomized rats, and its mechanism of action may be related to the inhibition of bone resorption.

[1] Chen Yuhua, Zhou Keyuan, Yuan Hanyao. Research progress on the efficacy of kaempferol [J]. Guangdong Medicine, 2010,31(08):1064-1066.
[2] Zhang Yawen, Shao Dongyan, Shi Junling, Zhu Jing, Huang Qingsheng, Yang Hui. Research progress on biological functions of kaempferol [J]. Life Science, 2017, 29(04): 400-405.
[3] CN201811455271.0 A preparation method of kaempferol

 

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