Benefits Of Fenbendazole in Animals

What is Fenbendazole?

 

Fenbendazole is a white or off-white powder, odorless and tasteless. This product is dissolved in dimethyl sulfoxide, slightly soluble in methanol, insoluble in water, dissolved in glacial acetic acid.

 

 

Pharmacological effects of fenbendazole

 

(1) Pharmacodynamics
Fenbendazole is a novel benzimidazole anthelmintic drug with broad spectrum, high efficiency and low toxicity. It not only has a high degree of dewormed activity against adult and larvae of animal gastrointestinal nematodes, but also has a good effect on reticula, Dicrocoelum spear, Fasciola and tapeworm. In foreign countries, fenbendazole is not only used for all kinds of animals, but also special preparations for wild animals.

(2) Pharmacokinetics
Because of the low solubility of fenbendazole, it is rarely absorbed when it is given to animals. For example, when it is given to sheep, cattle, and pigs, it is absorbed less, about 44%-50% of the prototype drug is excreted in feces, and less than 1% is excreted in urine. After oral administration, the blood of piglets reached the peak at 8 ~ 12 hours, and the half-life was 10 hours, while it took 24 ~ 30 hours for cattle and sheep to reach the peak, t1/2 was 25 ~ 30 hours, and t1/2 of rabbits was 15 hours. However, it can be excreted from the body of mice, rabbits and dogs 3 to 7 days after administration. After absorption, most of the metabolites of fenbendazole are formed in animals, such as in ruminants, mainly hydroxylation occurs on the benzene ring, and some also undergo deethoxycarbonylation. A large number of metabolites are also formed in pigs. Some studies have even confirmed that these metabolites in sheep can be secreted by the bile and then circulate to the liver and bow-organs.

fenbendazole Function

 

(1) Sheep had excellent deworming effect on the adults and larvae of Haemonchus ovinatus, Ostrella, Strongylus trichiura, Cupressaceae, Leptocercus, Solani, Charbertii, Ostomia, Trichiura and Reticula. In addition, it inhibits the oviposition of most gastrointestinal nematodes. The application of high limit dose also has good effect on sheep extended Monitz tapeworm and Monitz behnetii tapeworm. However, large doses must be used continuously to be effective against the trematode, such as 20mg/kg for 5 days and 15mg/kg for 6 days to eliminate Diploluma spears and Fasciola hepatica.

 

(2) The deworming spectrum of cattle to cattle was roughly similar to that of sheep. For example, it is highly effective against Haemonchus, Ostrella, Strongyloides, Tonostoma, Leptospira, Cupressaella, oesophagostoma, Reticulata viviparum adults and larvae. However, for Fasciola hepatica and Onchocerca anterioris, a dose of 7.5-10 mg/kg is required for 6 days to be effective. Fenbendazole also inhibited oviposition in nematodes. No eggs were excreted in the feces 22-36 hours after a single dose of medication.

 

(3) Horses were highly effective against Parascaris equis, the adults and larvae of Equinus equinus, viviparus prevotella, Round nematode common, Round nematode toothless, Round nematode equinus and small Round nematode. However, it is not effective against the larvae of the genera Daunchus, Gymnocephalus tapeworm, Strongyloides westermani and the common roundworm that is transferred to the mesentery.

 

(4) Pigs Although some people believe that a single administration of fenbendazole is effective against the adults and larvae of Strongyloides rubricoides, Ascaris lumbricoides, and oesophagostoma nematodes, the continuous administration of fenbendazole is currently recommended in the United States to enhance the deworming effect. For example, 15mg/kg of Trichinella solis was used once, and the efficacy was only 65%, while 3mg/kg was used for 6 days, and the efficacy was more than 99%. Due to the 3mg dose per kg body weight mixed feeding, it was used for 3 days. It has been widely used in foreign countries because of its effective dose of 25mg/kg for Ascaris lumbricoides, oesophagus, Strongyloides rubrum, and Chostrongyloides (the effective dose of one drug is 25mg/kg), and even the removal rate of Crocodontia (pig kidney worm) is almost 100%. In addition, it has good effect on the larvae of some insect species.

 

(5) A daily dose of 50mg/kg for 3 days was highly effective against hookworm, Ascaris lumbricoides and Trichiura in dogs and cats. A daily dose of 50mg/kg was used for 5 days to treat feline pneumophila (Strongyloides subcornicularis; Aelurostrongylus abstrusus); After 3 days of treatment, the mice were infected with cat stomach worms. 0llulanus) were the best deworming regimens.

 

(6) poultry has good effect on poultry gastrointestinal tract and respiratory tract nematodes. At a daily dose of 8mg/kg for 6 days, it was highly effective against Ascaris gallinarum, capillaria and tapeworm. A single effective dose of 350mg/kg was used against Turkey Ascaris lumbricoides, but if the feed concentration of 45mg/kg was fed for 6 days, all Turkey Ascaris lumbricoides, Anisakis and Trichiella sealis were removed. The optimal deworming regimen for pheasants, partridges, grouse, geese, and ducks is 60mg/kg feed concentration for 6 days. The pigeons naturally infected with Capillaria sealis and Ascaris pigeonlumbricoides were fed with 100mg/kg mixture for 3 or 4 days, and the effective rate was almost 100%.

 

(7) Wild animals Because fenbendazole is safe and reliable for the deworming of various wild animals in zoos, the US FDA has approved special preparations. It is briefly introduced as follows. To the lions, tigers and leopards of Toxocara carinalis, Toxocara carinalis, hookmouth nematode and tapeworm, the bears of Ascaris caris, Baylisascaris transtuga, and protostrongylus of Luojishan Bighorn sheep, lOmg per kilogram of body weight can be taken orally for 3 days. Daily doses of 2.5mg/kg and 3mg/kg were given to Haemonchus, Strongyloides, Trichiura, Trichiura of wild ruminants, hippopotamus, Ascaris lumbricoides of wild boars, Ostomia odonata and Crococerus odonata, respectively, for 3 days. Other data showed that feeding the birds of prey severely infected with Ascaris lumbricoides, Saulis, capillaria and trematodes at 25mg/kg for 3 days could almost eliminate the above parasites.

 

(8) Fenbendazole can kill the eggs of Trichomonas, Strongyloides suis and Ascaris gallinarum in ruminants, as well as hookworm and Trichuris trichiura eggs in humans and dogs.