Bovine Lactoferrin Powder

Lactoferrin is an important non-heme iron-binding glycoprotein with a molecular weight of 80 kDa, primarily expressed and secreted by mammary epithelial cells. As a member of the transferrin family, it is widely present in exocrine fluids such as mammalian milk, tears, and saliva, as well as in immune cells like neutrophils.

Lactoferrin competitively deprives bacteria of the iron they need for growth by chelating iron ions, thereby inhibiting bacterial growth. There are also studies showing that lactoferrin can bind to lipid A, causing lipid A to detach from the bacterial wall of Gram negative bacteria, leading to bacterial death. The N-terminus of lactoferrin contains a sequence encoding lactoferrin, which is an antimicrobial peptide with natural antibacterial activity known as the "immune milk gold", in infant formula milk powder Lactoferrin plays an important role in promoting the immune health of infants and young children. Lactoferrin is a natural protein with multiple physiological activities, involved in regulating immune function, antimicrobial activity, iron absorption, promoting intestinal cell proliferation and differentiation, and other pathological and physiological processes. In recent years, lactoferrin has been widely used in infants, pregnant women, and the elderly, which can reduce the risk of infection in premature infants, the incidence of respiratory and gastrointestinal diseases in infants and young children, improve anemia in infants and pregnant women, increase the cure rate of Helicobacter pylori in children and adults, and improve the immune function of the elderly.

Lactoferrin can act as an enzyme in certain catalytic reactions. There are significant similarities in certain motifs between lactoferrin and ribonuclease A. Lactoferrin has DNA binding characteristics and can play a role in transcriptional activation of specific DNA sequences or serve as a signal transduction mediator. Among all milk proteins, lactoferrin has the highest amylase and ATPase activity, however, they are not the only enzymatic activity.

The extensive biological functions of lactoferrin determine its applications in food, cosmetics, animal production, medical and other fields.

It can be used as an antioxidant, immune promoter, iron supplement, drug carrier, etc. Among them, it is particularly widely used in infant formula milk powder.

Food industry: As of 2021, there is a wide variety of products on the market containing lactoferrin, including yogurt, skim milk, health foods, and fermented dairy products. There are many benefits to adding lactoferrin to infant formula, including promoting iron absorption and improving gut microbiota. These products containing lactoferrin have been proven to be very beneficial to health in clinical and animal trials. It is popular in countries and regions such as Japan and South Korea to add lactoferrin to fermented dairy products, infant and toddler food, soy protein products, and meat products to supplement lactoferrin and enhance the body's immunity

Cosmetics: Lactoferrin is a natural substance in the human body that has a wide range of antibacterial, anti-inflammatory, melanin inhibiting, and collagen promoting effects. Therefore, it can be used as an effective ingredient in the development and utilization of cosmetic preparations. In the development of whitening cosmetics, the raw materials have a certain degree of stability during processing, and lactoferrin has extremely high stability and can be used as a raw material for processing into whitening agents. Studies have shown that using lactoferrin to identify its whitening function in animal skin models can reduce the formation of melanin, and its ability to inhibit melanin is directly proportional to the content of lactoferrin. This indicates that lactoferrin can be absorbed by the skin, thereby playing a whitening role. Lactoferrin can promote collagen synthesis in osteoblasts in the human body, compensate for the loss of collagen caused by age and environmental factors, and have a whitening effect on human skin. The whitening effect of lactoferrin is significant, and its application prospects in cosmetics are broad.

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